ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:

Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)

Biological characterization of new molecular entities in the context of drug discovery

Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.

Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry

Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources

Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response

Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic

Mechanistic drug metabolism and regulation of metabolic enzyme gene expression

Chemistry patents relevant to the medicinal chemistry field.